Contents:
GAYO BLASCO, SARA
Hope Hope Blazo Relativ Loretta Spears Bracey Sara Elizabeth Blaza Mill Valley, CA (Tamalpais Valley) Other Addrs Novato, CA Relativ Gayl A Sorato •. Vázquez-Castellanos, #1, 2 Serg Serrano-Villar, #3 Nuria Jiménez-Hernánz, 1 María Dolor Soto l R, 4 Sara Gayo, 1 David Rojo, 5 Manuel Ferrer, 5, 6 Coral Barbas, 5 Santiago Moreno, 3 Vicente Estrada, 7 Tomas Rattei, 8 Amparo Latorre, 1, 2, 9 Andrés Moya, #1, 2, 9 and María José Gosalb#1, 2AbstractHIV fectn a disptn of gut-associated lymphoid tissue, drivg a shift the posn of gut microbta. Then, we mapped all of the reads om each pathway bmarkers agast the reference genom of the speci bmarkers (see supplementary methods) eply study the metabolic pathways volved the flammatn produced by HIV fectn, we nducted a sensive search of remote gene homologs and speci that uld nta them the metagenomic and metatranscriptomic data.
Microbial metabolism of dietary tryptophan and choleTo study the role of HIV-associated microbta the pro-flammatory kynurene pathway, we nducted a sensive search of homolog gen the metagenomic and metatranscriptomic data sets. Remote gene homolog tectn om (a) metabolic rout of IDO1 tryptophan tabolism, (b) tryptophan fermentatn to dole and (c) fermentatn of chole and L-rne to TMA.
Th, we searched for the homolog gene of the cutC (Chole TMA Lyase) and cutD gen (Chole TMA−Lyase activatg prote) the metagenom and metatranscriptom of HIV− and HIV+ dividuals (Fig. We found few homolog gen that tabolized the transformatn of L-rne TMA (Fig.