JNCCN 360 - MM - Franc Gay, MD, on the FORTE Trial: Triplet Therapy for Newly Diagnosed Multiple Myeloma

Contents:

• FRANC GAY, MD, ON THE FORTE TRIAL: TRIPLET THERAPY FOR NEWLY DIAGNOSED MULTIPLE MYELOMA
• DR. GAY DISCS THE EFFICY DATA OM THE FORTE TRIAL MYELOMA

FRANC GAY, MD, ON THE FORTE TRIAL: TRIPLET THERAPY FOR NEWLY DIAGNOSED MULTIPLE MYELOMA

Gay et al. FigureDisclosurGay:Amgen: Honoraria, Membership on an enty's Board of Directors or advisory mte; Takeda: Honoraria, Membership on an enty's Board of Directors or advisory mte; Bristol-Myers Squibb: Honoraria, Membership on an enty's Board of Directors or advisory mte; Roche: Membership on an enty's Board of Directors or advisory mte; GSK: Membership on an enty's Board of Directors or advisory mte; AbbVie: Membership on an enty's Board of Directors or advisory mte; Adaptive: Membership on an enty's Board of Directors or advisory mte; Seattle Geics: Membership on an enty's Board of Directors or advisory mte; Onpeptis: Membership on an enty's Board of Directors or advisory mte; Janssen: Honoraria, Membership on an enty's Board of Directors or advisory mte; Celgene: Honoraria, Membership on an enty's Board of Directors or advisory mte.

Updated rults om the FORTE trial were recently published Lancet Onlogy by Franc Gay et al. *Adapted om Gay, et al. *Adapted om Gay et al.

DR. GAY DISCS THE EFFICY DATA OM THE FORTE TRIAL MYELOMA

*Data om Gay, et al. Gay F, Mto P, Rota-Slabri D, et al.

Gay F, Ma R, Rota-Slabriet D, al. Out of the FORTE trial, Gay and lleagu reported a PFS rate of 62% after four years HR patients treated wh upont KRd, ASCT, and KR or R matenance, however g a broad fn of HR acuntg for more than 50% of the trial populatn [9].

Ma R, Mto P, Rota-Slabri D, Paris L, Gamberi B, Palmas A, Aquo S, Fabriis P, Giuliani N, De Rosa L, Gozzetti A, Celli C, Bertami L, Capra A, Oddolo D, Vcelli ID, Ronni S, Pavone V, Psta N, Cea M, Froni F, Ballanti S, Grasso M, Zamagni E, Belotti A, Bocdoro M, Gay F.

Cavo M, Gay F, Beksac M, Pantani L, Petcci MT, Dimopoulos MA, Dozza L, van r Holt B, Zweegman S, Oliva S, van r Veln VHJ, Zamagni E, Palumbo GA, Patriar F, Montef V, Galli M, Maisnar V, Gamberi B, Hansson M, Belotti A, Pour L, Ypma P, Grasso M, Croockew A, Ballanti S, Offidani M, Vcelli ID, Zambello R, Liberati AM, Anrsen NF, Broijl A, Troia R, Pasrella A, Benevolo G, Lev MD, Bos G, Ludwig H, Aquo S, Morelli AM, Wu KL, Boersma R, Hajek R, Durian M, von m Borne PA, Carava di Torto T, Zanr T, Drisen C, Specchia G, Waage A, Gimsg P, Mellqvist UH, van Marwijk Kooy M, Mnema M, Mandigers C, Cao AM, Palmas A, Carvalho S, Spencer A, Bocdoro M, Sonneveld P. Gay F, Oliva S, Petcci MT, Conticello C, Catalano L, Corradi P, Sislchi A, Magarotto V, Pour L, Carella A, Malfano A, Petrò D, Evangelista A, Spada S, Psta N, Omedè P, Campbell P, Liberati AM, Offidani M, Ria R, Puli S, Patriar F, Hajek R, Spencer A, Bocdoro M, Palumbo A. Gay F, et al.

Franc Gay, MD, of GIMEMA, European Myeloma Network, discs the potential role of rfilzomib/lenalidomi/xamethasone wh or whout transplantatn ducg high-qualy rpons, achievg negative mimal ridual disease, and rcg the risk of early relapse. Franc Gay, MD, PhD, hematologist, Myeloma Un, Divisn of Hematology, Azienda Ospedaliero Universaria Ctà lla Salute e lla Scienza, discs the updated efficy data om the FORTE trial of patients wh newly-diagnosed multiple myeloma.

Franc Gay, MD, PhD, hematologist, Myeloma Un, Divisn of Hematology, Azienda Ospedaliero Universaria Ctà lla Salute e lla Scienza, discs the updated efficy data om the FORTE trial of patients wh newly-diagnosed multiple the study of 474 patients, 315 were treated wh rfilzomib (Kyprolis), lenalidomi (Revlimid) and xamethasone (KRd), and 159 were treated wh rfilzomib, cyclophosphami and xamethasone (KCd). The rate of partial rponse (PR) after ductn was very high both arms, Gay says, wh a 97% PR patients treated wh KRd, and a 91% PR patients treated wh KCd.

Dr Franc Gay (GIMEMA, European Myeloma Network, Italy) prented the most recent a median follow-up om first randomisatn of 45 months, median PFS was not reached wh KRd_ASCT, PFS was 57 months wh KRd12, and 53 months wh KCd_ASCT: KRd_ASCT vs KCd_ASCT: HR 0. Prented ByDr Franc Gay, GIMEMA, European Myeloma Network, Italy. Franc Gay, MD, Pellegro Mto, Delia Rota Slabri*, Moni Galli*, Angelo Belotti, MD*, Elena Zamagni, MD*, Lu Bertami, MD*, Renato Zambello*, Mil Quarima*, Gvanni De Sabbata*, Gieppe Pietrantuono*, Mattia D'Agosto, MD*, Daniela Oddolo*, Andrea Capra*, Anna Mara Liberati*, Salvatore Palmieri*, Fran Narni, Massimo Offidani, Michele Cavo* and Mar BocdoroGIMEMA, European Myeloma Network, Italy.