There’s (Still) No Gay Gene | Harvard Magaze

Contents:

• THERE IS NO ‘GAY GENE.’ THERE IS NO ‘STRAIGHT GENE.’ SEXUALY IS JT PLEX, STUDY NFIRMS
• THERE’S (STILL) NO GAY GENE
• NO ‘GAY GENE’: MASSIVE STUDY HOM ON GEIC BASIS OF HUMAN SEXUALY
• THERE’S NO ONE ‘GAY GENE,’ BUT GEICS ARE LKED TO SAME-SEX BEHAVR, NEW STUDY SAYS
• SEARCH FOR 'GAY GEN' COM UP SHORT IN LARGE NEW STUDY
• WHY ARE PEOPLE GAY? GAY BY CHOICE OR IS BEG GAY GEIC?
• IS THERE A "GAY GENE"? MAJOR NEW STUDY SAYS NO
• THE REAL STORY ON GAY GEN
• WHAT DO THE NEW ‘GAY GEN’ TELL ABOUT SEXUAL ORIENTATN?
• THE 'GAY GENE' IS A TOTAL MYTH, MASSIVE STUDY CONCLUS
• THE 'GAY GENE' IS A MYTH BUT BEG GAY IS 'NATURAL,' SAY SCIENTISTS
• IS THERE A “GAY GENE"?

THERE IS NO ‘GAY GENE.’ THERE IS NO ‘STRAIGHT GENE.’ SEXUALY IS JT PLEX, STUDY NFIRMS

It is worth keepg md that this study only vers some typ of sexualy — gay, lbian and cis-straight — but don’t offer many sights to genr inty. Humans have tried to unrstand human sexualy for centuri — and geics rearchers joed the ay the early 1990s after a seri of studi on tws suggted homosexualy ran fai.

“As a teenager tryg to unrstand myself and unrstand my sexualy, I looked at the ter for “the gay gene” and obvly me across Xq28, ” said Fah Sathirapongsasuti, a study -thor and senr scientist at 23andMe, which he joked once led him to believe he hered his gayns om his mother. “We worried a lot about volunteer bias, ” said Bailey, whose rearch clus a wily publicized study on Xq28 and gay brothers om 2018. The rearchers had members of the same-sex muny review the study’s sign and language, and they adm that their termology and fns for gay, lbian and heterosexual do not reflect the full nature of the sexualy ntuum.

THERE’S (STILL) NO GAY GENE

“[Our study] unrsr an important role for the environment shapg human sexual behavr and perhaps most importantly there is no sgle gay gene but rather the ntributn of many small geic effects sttered across the genome, ” Neale said. There is no one gene for beg gay, and though gen seem to play a role termg sexual orientatn and same-sex behavr, ’s small, plex, and anythg but termistic.

“There is no sgle gay gene, but rather the ntributn of many small geic effects sttered across the genome, ” he emphasized. “We know that smell has a strong tie to sexual attractn, but s lks to sexual behavrs are not clear, ” said -thor Andrea Ganna, an stctor at HMS and Massachetts General Hospal om the Instute for Molecular Medice study is part a rponse to gay, lbian, and bisexual people’s cursy about themselv, said Fah Sathirapongsasuti, a senr scientist at 23andMe and -thor on the study, who is himself gay. Michael Bronski, profsor of the practice media and activism wh the mtee on studi of women, genr, and sexualy, and thor of A Queer History of the Uned Stat, says the allure of a “gay gene” grew om the flourishg gay-rights movement the after the Stonewall rts 1969.

Conservative opponents of the movement claimed that “homosexual acts are a choice, people choose to m them, or people are sced to the gay liftyle, ” he explas.

NO ‘GAY GENE’: MASSIVE STUDY HOM ON GEIC BASIS OF HUMAN SEXUALY

’77, then a rearcher at the Natnal Instut of Health, published rults showg a rrelatn between male homosexual behavr and a clter of gen, lled Xq28, at the tip of the X chromosome. Exactly which gene this clter may be volved has proven elive—the current study found no signifint associatn between the X chromosome and same-sex sexual behavr—but the ia that a “gay gene” might lie somewhere Xq28—or elsewhere—was ptivatg.

Zeke Stok, chief programs officer of the LGBTQ advocy anizatn GLAAD, ncurred an emailed statement: “This new study provis even more evince that beg gay or lbian is a natural part of human life, a ncln that has been drawn by rearchers and scientists time and aga. Others have warned that the search for a geic e would pathologize homosexualy the same way psychology did the twentieth century: efforts by psychoanalysts such as Irvg Bieber led to the cln of homosexualy the Amerin Psychiatric Associatn’s Diagnostic and Statistil Manual of Mental Disorrs until 1972.

THERE’S NO ONE ‘GAY GENE,’ BUT GEICS ARE LKED TO SAME-SEX BEHAVR, NEW STUDY SAYS

As noted above, the gen that rrelated wh same-sex sexual behavr also rrelated wh willgns to take risks, a nnectn that might not hold up cultur where homosexualy is ls stigmatized and those who are ls risk tolerant would therefore feel more able to act openly.

“There is no ‘gay gene’, ” says lead study thor Andrea Ganna, a geicist at the Broad Instute of MIT and Harvard Cambridge, and his lleagu also ed the analysis to timate that up to 25% of sexual behavur n be explaed by geics, wh the rt fluenced by environmental and cultural factors — a figure siar to the fdgs of smaller studi.

The rearchers say that, although variatns the gen nnot predict whether a person is gay, the variants may partly fluence sexual Ganna, lead thor and European Molecular Blogy Laboratory group lear at the Instute of Molecular Medice Fland, said the rearch rerc the unrstandg that same-sex sexual behavr is simply “a natural part of our diversy as a speci.

SEARCH FOR 'GAY GEN' COM UP SHORT IN LARGE NEW STUDY

Some of the variants were rrelated wh same-sex sexual behavr men, others women, and some Vila, director of the Center for Geic Medice Rearch at Children’s Natnal Health System, said the study marks the end of “the simplistic ncept of the ‘gay gene. Environmental effects may be a factor for some people; for stance, havg olr brothers creas the odds that younger brothers will be gay, which rearchers spect may have to do wh chang to the mother’s immune system rponse to the earlier Stok, chief programs officer for GLAAD, said a statement that the new rearch on the geics “provis even more evince that beg gay or lbian is a natural part of human life, a ncln that has been drawn by rearchers and scientists time and aga.

This new rearch also renfirms the long tablished unrstandg that there is no nclive gree to which nature or nurture fluence how a gay or lbian person behav. And bee the rearchers didn't fd gene variants that rrelated wh a gradient of sexual behavr, she says, unrcuts Aled Ksey's s-old sle, which ranked people on a spectm of sexualy, om exclively heterosexual to exclively homosexual.

WHY ARE PEOPLE GAY? GAY BY CHOICE OR IS BEG GAY GEIC?

In other words, 5-10% of people experience same-sex sexual attractn or behavr; of urse, this don't speak to what mak people gay. It very much appears that same-sex sexual attractn is not a choice but actg on is; so if you fe gay as the mere prence of same-sex attractn, then om everythg we unrstand, beg gay is not a choice. If, on the other hand, you nsir someone to be gay only if they act on their same-sex attractn then beg gay n be nsired a choice pendg on an dividual's behavr.

IS THERE A "GAY GENE"? MAJOR NEW STUDY SAYS NO

Whether science n ultimately prove the blogy of beg gay or not, 's important to support all adults their choic no matter how they intify. There's no such thg as a sgle "gay gene" that driv a person's sexual behavr, nclus the largt geic study ever nducted on the issue.

"This new study provis even more evince that that beg gay or lbian is a natural part of human life, a ncln that has been drawn by rearchers and scientists time and aga, " said GLAAD Chief Programs Officer Zeke Stok. This new rearch also renfirms the long-tablished unrstandg that there is no nclive gree to which nature or nurture fluence how a gay or lbian person behav. "This reflects voic om the LGBTQ+ (lbian, gay, bisexual, transgenr, queer+) muny argug that a range of sexuali exist, " Mills wrote.

Those who nsir beg gay a disadvantage life (which still is, certa societi), might regard gay people differently if they knew that beg gay was an hered tra, rather than a nsequence of life events, such as a particular type of upbrgg, or mixg wh certa sorts of iends or even a liberate cisn. An early study claimed that if one pair of (male) intil tws (who have intil geic patterns) was gay, there was a 100 percent chance of the other one also beg gay. It was quickly shown that, fact, the real chance of two intil tws beg gay was around 40-50 percent, whereas was ls non-intil on, though still somewhat greater than the general populatn.

THE REAL STORY ON GAY GEN

There was another, much smaller, group who said they were entirely gay (about 6 percent), and a stterg of even smaller numbers who claimed to be bisexual. However, blogists have documented homosexual behavr more than 450 speci, argug that same-sex behavr is not an unnatural choice, and may fact play a val role wh populatns.

The 2019 study is the latt a hunt for “gay gen” that began 1993, when Dean Hamer lked male homosexualy to a sectn of the X chromosome. As the ease and affordabily of genome sequencg creased, addnal gene ndidat have emerged wh potential lks to homosexual behavr. So-lled genome-wi associatn studi intified a gene lled SLITRK6, which is active a bra regn lled the diencephalon that differs size between people who are homosexual or heterosexual.

” For example, certa gen women help crease their fertily, but if the gen are exprsed a male, they predispose him toward homosexualy.

WHAT DO THE NEW ‘GAY GEN’ TELL ABOUT SEXUAL ORIENTATN?

While there is no sgle “gay gene, ” there is overwhelmg evince of a blogil basis for sexual orientatn that is programmed to the bra before birth based on a mix of geics and prenatal ndns, none of which the fet choos.

Still others, backg the same e, disurage any vtigatn to the blogil origs of sexual orientatn, fearful that posive rults will lead to attempts to rid the world of potential homosexuals. For them, the disvery of how an dividual be gay is likely to shed light on how sexualy-related gen build bras, how people of any persuasn are attracted to each other, and perhaps even how homosexualy evolved.

Hamer had jt published a study that claimed not only to have fally proved that male homosexualy was at least partially geic but also to have ppoted the stretch of chromosome where one of the gen volved rid.

THE 'GAY GENE' IS A TOTAL MYTH, MASSIVE STUDY CONCLUS

Hamer and his lleagu nducted extensive terviews wh 76 pairs of gay brothers and their fay members and found that homosexualy seemed to be hered through the maternal le. Studi have shown that women rpond to all typ of sexual pictns—not only heterosexual and homosexual imag but even those of chimpanze havg sex. For a long perd NIH grant proposals that clud words like “gay, ” “ndom, ” or even “sexualy” were turned down, much to the ire of rearchers like Hamer.

THE 'GAY GENE' IS A MYTH BUT BEG GAY IS 'NATURAL,' SAY SCIENTISTS

Shortly after he published his gay brothers study, Hamer pleted a siarly signed fay study lookg to a geic e for a certa kd of anxiety.

IS THERE A “GAY GENE"?

Yet Hamer ntends that his rults suggt there is a lk to Xq28 and that the Rice study was biased bee one of the thors told Hamer that he didn’t believe a gay gene uld exist. Whether or not a gay gene, a set of gay gen, or some other blogil mechanism is ever found, one thg is clear: The environment a child grows up has nothg to do wh what mak most gay men gay. Ially, Bocklandt would sn the genome of each dividual, lookg for a methylatn pattern anywhere on any chromosome that shows up repeatedly the gay member of each tw pair.

Alan Sanrs, an associate profsor of psychiatry at Northwtern, will be lookg at the whole genome of about 1, 000 gay brothers g the geic marker technique that Hamer ed.

By settg up a stand at Gay Pri paras and approachg “gay iendly” groups like PFLAG (Parents, Fai and Friends of Lbians and Gays), Sanrs has found more than 4, 000 gay men wh a brother who are terted participatg. He has already started mappg the first 500 and timat that by mid-2008 the world will know where—if anywhere—to fd the gay gene. ” The qutn of whether there is a gay gene—and if so, where ris—is hardly the only qutn about sexual orientatn that remas unanswered.