There’s no ‘gay gene,’ but geics are lked to same-sex behavr, new study says - The Washgton Post

Contents:

• THERE IS NO ‘GAY GENE.’ THERE IS NO ‘STRAIGHT GENE.’ SEXUALY IS JT PLEX, STUDY NFIRMS
• THE LIFE OF THE GAY GENE: OM HYPOTHETIL GEIC MARKER TO SOCIAL REALY
• NO ‘GAY GENE’: MASSIVE STUDY HOM ON GEIC BASIS OF HUMAN SEXUALY
• THERE’S NO ONE ‘GAY GENE,’ BUT GEICS ARE LKED TO SAME-SEX BEHAVR, NEW STUDY SAYS
• LARGT STUDY OF GAY BROTHERS HOM ON 'GAY GEN'
• 'GAY GEN': SCIENCE IS ON THE RIGHT TRACK, WE'RE BORN THIS WAY. LET’S AL WH .
• SCIENTISTS FD DNA DIFFERENC BETWEEN GAY MEN AND THEIR STRAIGHT TW BROTHERS
• A NEW AGE OF GAY GENOMICS IS HERE. ARE WE READY FOR THE CONSEQUENC?
• RETIRG THE SGLE GAY GENE HYPOTHIS
• STUDY SUGGTS MAL WH OLR BROTHER MORE LIKELY TO BE GAY

THERE IS NO ‘GAY GENE.’ THERE IS NO ‘STRAIGHT GENE.’ SEXUALY IS JT PLEX, STUDY NFIRMS

Those who nsir beg gay a disadvantage life (which still is, certa societi), might regard gay people differently if they knew that beg gay was an hered tra, rather than a nsequence of life events, such as a particular type of upbrgg, or mixg wh certa sorts of iends or even a liberate cisn. It was quickly shown that, fact, the real chance of two intil tws beg gay was around 40-50 percent, whereas was ls non-intil on, though still somewhat greater than the general populatn.

In theory, humans and other animals who are exclively attracted to others of the same sex should be unlikely to produce many blogil children, so any gen that predispose people to homosexualy would rarely be passed on to future generatns. Yet same-sex attractn is wispread humans, and rearch suggts that is partly a study of data om hundreds of thoands of people, rearchers have now intified geic patterns that uld be associated wh homosexual behavur, and showed how the might also help people to fd different-sex mat, and reproduce. Most of the participants were born durg a time when homosexualy was eher illegal or culturally taboo their untri, so many people who were attracted to others of the same sex might never have actually acted on their attractn, and uld therefore have end up the wrong group the Monk, an elogist and evolutnary blogist at Yale Universy New Haven, Connecticut, thks that the veats are so important that the paper n’t draw any real nclns about geics and sexual orientatn.

Instead, he thks the rearchers have found geic markers associated wh openns to new experienc, which uld expla the overlap between people who have had a homosexual partner and heterosexual people who have had many partners.

THE LIFE OF THE GAY GENE: OM HYPOTHETIL GEIC MARKER TO SOCIAL REALY

“As a teenager tryg to unrstand myself and unrstand my sexualy, I looked at the ter for “the gay gene” and obvly me across Xq28, ” said Fah Sathirapongsasuti, a study -thor and senr scientist at 23andMe, which he joked once led him to believe he hered his gayns om his mother.

The rearchers had members of the same-sex muny review the study’s sign and language, and they adm that their termology and fns for gay, lbian and heterosexual do not reflect the full nature of the sexualy ntuum. “[Our study] unrsr an important role for the environment shapg human sexual behavr and perhaps most importantly there is no sgle gay gene but rather the ntributn of many small geic effects sttered across the genome, ” Neale said. Intertgly, Wtern society, homosexual men, pared wh heterosexual men, tend to rell higher levels of separatn anxiety—the distrs rultg om beg separated om major attachment figur, such as one’s primary regiver or close fay members.

So-lled genome-wi associatn studi intified a gene lled SLITRK6, which is active a bra regn lled the diencephalon that differs size between people who are homosexual or heterosexual. While there is no sgle “gay gene, ” there is overwhelmg evince of a blogil basis for sexual orientatn that is programmed to the bra before birth based on a mix of geics and prenatal ndns, none of which the fet choos. Scientists may have fally solved the puzzle of what mak a person gay, and how is passed om parents to their children.A group of scientists suggted Tuday that homosexuals get that tra om their oppose-sex parents: A lbian will almost always get the tra om her father, while a gay man will get the tra om his mother.The heredary lk of homosexualy has long been tablished, but scientists knew was not a strictly geic lk, bee there are many pairs of intil tws who have differg sexuali.

NO ‘GAY GENE’: MASSIVE STUDY HOM ON GEIC BASIS OF HUMAN SEXUALY

Scientists om the Natnal Instute for Mathematil and Blogil Synthis say homosexualy seems to have an epigeic, not a geic lk.Long thought to have some sort of heredary lk, a group of scientists suggted Tuday that homosexualy is lked to epi-marks — extra layers of rmatn that ntrol how certa gen are exprsed. In homosexuals, the epi-marks aren't erased — they're passed om father-to-dghter or mother-to-son, explas William Rice, an evolutnary blogist at the Universy of California Santa Barbara and lead thor of the study."There is pellg evince that epi-marks ntribute to both the siary and dissiary of fay members, and n therefore feasibly ntribute to the observed faial herance of homosexualy and s low nrdance between [intil] tws," Rice not.Rice and his team created a mathematil mol that explas why homosexualy is passed through epi-marks, not geics.

But bee the epi-marks provi an evolutnary advantage for the parents of homosexuals: They protect fathers of homosexuals om unrexposure to ttosterone and mothers of homosexuals om overexposure to ttosterone while they are gtatn."The epi-marks protect fathers and mothers om excs or unrexposure to ttosterone — when they rry over to oppose-sex offsprg, n e the masculizatn of femal or the femizatn of mal," Rice says, which n lead to a child beg gay. Rice not that the markers are "highly variable" and that only strong epi-marks will rult a homosexual offsprg.Though scientists have long spected some sort of geic lk, Rice says studi attemptg to expla why people are gay have been few and far between."Most mastream blogists have shied away om studyg bee of the social stigma," he says.

Well there are many exampl of homosexualy nature, 's very mon." Homosexual behavr has been observed black swans, pengus, sheep, and other animals, he says.Rice's mol still needs to be tted on real-life parent-offsprg pairs, but he says this epigeic lk mak more sense than any other explanatn, and that his team has mapped out a way for other scientists to tt their work."We've found a story that looks really good," he says.

THERE’S NO ONE ‘GAY GENE,’ BUT GEICS ARE LKED TO SAME-SEX BEHAVR, NEW STUDY SAYS

They asked more than 477, 000 participants whether they had ever had sex wh someone of the same sex, and also qutns about sexual fantasi and the gree to which they intified as gay or straight.

“A lot of people want to unrstand the blogy of homosexualy, and science has lagged behd that human tert, ” says William Rice, an evolutnary geicist at the Universy of California, Santa Barbara, who also was not volved the work. Public opn studi over the 1970s, 1980s, and 1990s routely showed that, among large segments of the public, lbian, gay, and bisexual people were the target of strongly held negative attus.

LARGT STUDY OF GAY BROTHERS HOM ON 'GAY GEN'

The associatn of HIV/AIDS wh gay and bisexual men and the accurate belief that some people held that all gay and bisexual men were fected served to further stigmatize lbian, gay, and bisexual people. Dpe the persistence of stereotyp that portray lbian, gay, and bisexual people as disturbed, several s of rearch and clil experience have led all mastream medil and mental health anizatns this untry to nclu that the orientatns reprent normal forms of human experience.

Helpful rpons of a therapist treatg an dividual who is troubled about her or his same sex attractns clu helpg that person actively pe wh social prejudic agast homosexualy, succsfully rolve issu associated wh and rultg om ternal nflicts, and actively lead a happy and satisfyg life. The phrase “g out” is ed to refer to several aspects of lbian, gay, and bisexual persons’ experienc: self-awarens of same-sex attractns; the tellg of one or a few people about the attractns; wispread disclosure of same-sex attractns; and intifitn wh the lbian, gay, and bisexual muny. Th, is not surprisg that lbians and gay men who feel they mt nceal their sexual orientatn report more equent mental health ncerns than do lbians and gay men who are more open; they may even have more physil health problems.

Lbian, gay, and bisexual youth who do well spe strs—like all adolcents who do well spe strs—tend to be those who are socially petent, who have good problem-solvg skills, who have a sense of tonomy and purpose, and who look forward to the future.

'GAY GEN': SCIENCE IS ON THE RIGHT TRACK, WE'RE BORN THIS WAY. LET’S AL WH .

If they are a heterosexual relatnship, their experienc may be que siar to those of people who intify as heterosexual unls they choose to e out as bisexual; that se, they will likely face some of the same prejudice and discrimatn that lbian and gay dividuals enunter.

For example, are the children of lbian or gay parents more vulnerable to mental breakdown, do they have more behavr problems, or are they ls psychologilly healthy than other children?

SCIENTISTS FD DNA DIFFERENC BETWEEN GAY MEN AND THEIR STRAIGHT TW BROTHERS

The picture that emerg om this rearch shows that children of gay and lbian parents enjoy a social life that is typil of their age group terms of volvement wh peers, parents, fay members, and iends.

In summary, social science has shown that the ncerns often raised about children of lbian and gay parents, ncerns that are generally ground prejudice agast and stereotyp about gay people, are unfound. Overall, the rearch dit that the children of lbian and gay parents do not differ markedly om the children of heterosexual parents their velopment, adjtment, or overall well-beg. Lbian, gay, and bisexual people who want to help rce prejudice and discrimatn n be open about their sexual orientatn, even as they take necsary preutns to be as safe as possible.

When lbians, gay men, and bisexual people feel ee to make public their sexual orientatn, heterosexuals are given an opportuny to have personal ntact wh openly gay people and to perceive them as dividuals. Antigay attus are far ls mon among members of the populatn who have a close iend or fay member who is lbian or gay, pecially if the gay person has directly e out to the heterosexual person. “There is no ‘gay gene’, ” says lead study thor Andrea Ganna, a geicist at the Broad Instute of MIT and Harvard Cambridge, and his lleagu also ed the analysis to timate that up to 25% of sexual behavur n be explaed by geics, wh the rt fluenced by environmental and cultural factors — a figure siar to the fdgs of smaller studi.

A NEW AGE OF GAY GENOMICS IS HERE. ARE WE READY FOR THE CONSEQUENC?

The rearchers say that, although variatns the gen nnot predict whether a person is gay, the variants may partly fluence sexual Ganna, lead thor and European Molecular Blogy Laboratory group lear at the Instute of Molecular Medice Fland, said the rearch rerc the unrstandg that same-sex sexual behavr is simply “a natural part of our diversy as a speci. Some of the variants were rrelated wh same-sex sexual behavr men, others women, and some Vila, director of the Center for Geic Medice Rearch at Children’s Natnal Health System, said the study marks the end of “the simplistic ncept of the ‘gay gene.

RETIRG THE SGLE GAY GENE HYPOTHIS

Environmental effects may be a factor for some people; for stance, havg olr brothers creas the odds that younger brothers will be gay, which rearchers spect may have to do wh chang to the mother’s immune system rponse to the earlier Stok, chief programs officer for GLAAD, said a statement that the new rearch on the geics “provis even more evince that beg gay or lbian is a natural part of human life, a ncln that has been drawn by rearchers and scientists time and aga.

Sanrs says he has already pleted the work for that next step: he has pared SNPs those specific regns gay and straight men to see if there are obv differenc the gene variants, and is now preparg the rults for publitn. “This study knocks another nail to the ff of the ‘chosen liftyle’ theory of homosexualy, ” says Simon LeVay, the nroscientist and wrer who, 1991, claimed to have found that a specific bra regn, wh the hypothalam, is smaller gay men. “Y, we have a choice life, to be ourselv or to nform to someone else’s ia of normaly, but beg straight, bisexual or gay, or none of the, is a central part of who we are, thanks part to the DNA we were born wh.

The gen, if and when they are intified, may only predispose one to the possibily of beg gay, should the required environmental, nutrnal or other unknown factors be prent at cril stag of velopment. How Olr Brothers Influence HomosexualyHomosexualy might be partly driven by a mother’s immune rponse to her male fet—which creas wh each son she MacGregor / RtersHere’s what we know: Homosexualy is normal.

STUDY SUGGTS MAL WH OLR BROTHER MORE LIKELY TO BE GAY

Female Japane maqu will even pete tersexually wh mal for exclive accs to female sexual ’s what we don’t know: What, specifilly, someone to bee gay, straight, or somethg between. Part of the explanatn is geic, but bee most intil tws of gay people are straight, heredy don’t expla “why” qutn is important bee “there is a strong rrelatn between beliefs about the origs of sexual orientatn and tolerance of non-heterosexualy, ” acrdg to the report thors, who are om seven universi spanng the globe. (When Atlantic ntributor Chandler Burr proposed his 1996 book, A Separate Creatn, that people are born gay, Southern Baptists lled to boytt Disney films and parks prott agast the publisher, Disney subsidiary Hypern.

) It shouldn’t matter whether people “choose” to be gay, but polilly, do—at least for of the most nsistent environmental explanatns for homosexualy is lled the “aternal birth orr effect. But gaps will rema, such as why some firstborn sons are gay, why some intil tws of gay sons are straight, and why women are gay, to name jt a review-paper thors do le out one explanatn for homosexualy, however: That tolerance for gay people enurag more people to bee gay.

“Homosexual orientatn do not crease equency wh social tolerance, although s exprsn ( behavr and open intifitn) may do so, ” they reasong—that a tolerant society somehow enurag homosexualy to flourish—has been ed to support anti-gay legislatn Uganda, Rsia, and elsewhere. Fdg evince for a blogil basis should not sre or unrme gay, lbian and bisexual (LGB) rights (the studi I refer to do not clu transgenred dividuals, so I’ll nfe my ments to lbian, gay and bisexual people). Evince om pennt rearch groups who studied tws shows that geic factors expla about 25-30% of the differenc between people sexual orientatn (heterosexual, gay, lbian, and bisexual).