There’s (Still) No Gay Gene | Harvard Magaze

Contents:

• THERE IS NO ‘GAY GENE.’ THERE IS NO ‘STRAIGHT GENE.’ SEXUALY IS JT PLEX, STUDY NFIRMS
• THERE’S NO ONE ‘GAY GENE,’ BUT GEICS ARE LKED TO SAME-SEX BEHAVR, NEW STUDY SAYS
• SEARCH FOR 'GAY GEN' COM UP SHORT IN LARGE NEW STUDY
• THERE’S (STILL) NO GAY GENE
• THE 'GAY GENE' IS A MYTH BUT BEG GAY IS 'NATURAL,' SAY SCIENTISTS
• WHAT DO THE NEW ‘GAY GEN’ TELL ABOUT SEXUAL ORIENTATN?
• GAY GEICSMOST OF BELIEVE THAT WE WERE BORN THAT WAY, BUT IS SEXUAL ORIENTATN OUR DNA? JV CHAMARY GO SEARCH OF THE GAY GENEJV CHAMARYPUBLISHED: MAY 31, 2009 AT 11:00 PMGAY GEICS
• IS THERE A 'GAY GENE'? THE PROBLEM WH STUDI NNECTG GEICS AND LGBTQ INTY
• THE 'GAY GENE' IS A TOTAL MYTH, MASSIVE STUDY CONCLUS
• 'GAY GEN': SCIENCE IS ON THE RIGHT TRACK, WE'RE BORN THIS WAY. LET’S AL WH .
• NO ‘GAY GENE’: MASSIVE STUDY HOM ON GEIC BASIS OF HUMAN SEXUALY
• MANY GEN INFLUENCE SAME-SEX SEXUALY, NOT A SGLE ‘GAY GENE’
• IS THERE A “GAY GENE"?
• IS THERE A "GAY GENE"? MAJOR NEW STUDY SAYS NO

THERE IS NO ‘GAY GENE.’ THERE IS NO ‘STRAIGHT GENE.’ SEXUALY IS JT PLEX, STUDY NFIRMS

It is worth keepg md that this study only vers some typ of sexualy — gay, lbian and cis-straight — but don’t offer many sights to genr inty. Humans have tried to unrstand human sexualy for centuri — and geics rearchers joed the ay the early 1990s after a seri of studi on tws suggted homosexualy ran fai. “As a teenager tryg to unrstand myself and unrstand my sexualy, I looked at the ter for “the gay gene” and obvly me across Xq28, ” said Fah Sathirapongsasuti, a study -thor and senr scientist at 23andMe, which he joked once led him to believe he hered his gayns om his mother.

The rearchers had members of the same-sex muny review the study’s sign and language, and they adm that their termology and fns for gay, lbian and heterosexual do not reflect the full nature of the sexualy ntuum. “[Our study] unrsr an important role for the environment shapg human sexual behavr and perhaps most importantly there is no sgle gay gene but rather the ntributn of many small geic effects sttered across the genome, ” Neale said. However, blogists have documented homosexual behavr more than 450 speci, argug that same-sex behavr is not an unnatural choice, and may fact play a val role wh populatns.

So-lled genome-wi associatn studi intified a gene lled SLITRK6, which is active a bra regn lled the diencephalon that differs size between people who are homosexual or heterosexual. While there is no sgle “gay gene, ” there is overwhelmg evince of a blogil basis for sexual orientatn that is programmed to the bra before birth based on a mix of geics and prenatal ndns, none of which the fet choos.

THERE’S NO ONE ‘GAY GENE,’ BUT GEICS ARE LKED TO SAME-SEX BEHAVR, NEW STUDY SAYS

The rearchers say that, although variatns the gen nnot predict whether a person is gay, the variants may partly fluence sexual Ganna, lead thor and European Molecular Blogy Laboratory group lear at the Instute of Molecular Medice Fland, said the rearch rerc the unrstandg that same-sex sexual behavr is simply “a natural part of our diversy as a speci.

Some of the variants were rrelated wh same-sex sexual behavr men, others women, and some Vila, director of the Center for Geic Medice Rearch at Children’s Natnal Health System, said the study marks the end of “the simplistic ncept of the ‘gay gene.

Environmental effects may be a factor for some people; for stance, havg olr brothers creas the odds that younger brothers will be gay, which rearchers spect may have to do wh chang to the mother’s immune system rponse to the earlier Stok, chief programs officer for GLAAD, said a statement that the new rearch on the geics “provis even more evince that beg gay or lbian is a natural part of human life, a ncln that has been drawn by rearchers and scientists time and aga. This new rearch also renfirms the long tablished unrstandg that there is no nclive gree to which nature or nurture fluence how a gay or lbian person behav.

SEARCH FOR 'GAY GEN' COM UP SHORT IN LARGE NEW STUDY

Those who nsir beg gay a disadvantage life (which still is, certa societi), might regard gay people differently if they knew that beg gay was an hered tra, rather than a nsequence of life events, such as a particular type of upbrgg, or mixg wh certa sorts of iends or even a liberate cisn. An early study claimed that if one pair of (male) intil tws (who have intil geic patterns) was gay, there was a 100 percent chance of the other one also beg gay. It was quickly shown that, fact, the real chance of two intil tws beg gay was around 40-50 percent, whereas was ls non-intil on, though still somewhat greater than the general populatn.

THERE’S (STILL) NO GAY GENE

There was another, much smaller, group who said they were entirely gay (about 6 percent), and a stterg of even smaller numbers who claimed to be bisexual.

THE 'GAY GENE' IS A MYTH BUT BEG GAY IS 'NATURAL,' SAY SCIENTISTS

In theory, humans and other animals who are exclively attracted to others of the same sex should be unlikely to produce many blogil children, so any gen that predispose people to homosexualy would rarely be passed on to future generatns. Yet same-sex attractn is wispread humans, and rearch suggts that is partly a study of data om hundreds of thoands of people, rearchers have now intified geic patterns that uld be associated wh homosexual behavur, and showed how the might also help people to fd different-sex mat, and reproduce.

The thors say their fdgs, published on 23 Augt Nature Human Behavur1, uld help to expla why gen that predispose people to homosexualy ntue to be passed down. Most of the participants were born durg a time when homosexualy was eher illegal or culturally taboo their untri, so many people who were attracted to others of the same sex might never have actually acted on their attractn, and uld therefore have end up the wrong group the Monk, an elogist and evolutnary blogist at Yale Universy New Haven, Connecticut, thks that the veats are so important that the paper n’t draw any real nclns about geics and sexual orientatn.

Instead, he thks the rearchers have found geic markers associated wh openns to new experienc, which uld expla the overlap between people who have had a homosexual partner and heterosexual people who have had many partners. And he adms that g a sgle homosexual experience as an ditn of sexual orientatn isn’t ial, but says that the UK Bbank didn’t provi data on attractn.

WHAT DO THE NEW ‘GAY GEN’ TELL ABOUT SEXUAL ORIENTATN?

And bee the rearchers didn't fd gene variants that rrelated wh a gradient of sexual behavr, she says, unrcuts Aled Ksey's s-old sle, which ranked people on a spectm of sexualy, om exclively heterosexual to exclively homosexual. There is no one gene for beg gay, and though gen seem to play a role termg sexual orientatn and same-sex behavr, ’s small, plex, and anythg but termistic.

“We know that smell has a strong tie to sexual attractn, but s lks to sexual behavrs are not clear, ” said -thor Andrea Ganna, an stctor at HMS and Massachetts General Hospal om the Instute for Molecular Medice study is part a rponse to gay, lbian, and bisexual people’s cursy about themselv, said Fah Sathirapongsasuti, a senr scientist at 23andMe and -thor on the study, who is himself gay. Michael Bronski, profsor of the practice media and activism wh the mtee on studi of women, genr, and sexualy, and thor of A Queer History of the Uned Stat, says the allure of a “gay gene” grew om the flourishg gay-rights movement the after the Stonewall rts 1969.

Conservative opponents of the movement claimed that “homosexual acts are a choice, people choose to m them, or people are sced to the gay liftyle, ” he explas. ’77, then a rearcher at the Natnal Instut of Health, published rults showg a rrelatn between male homosexual behavr and a clter of gen, lled Xq28, at the tip of the X chromosome. Exactly which gene this clter may be volved has proven elive—the current study found no signifint associatn between the X chromosome and same-sex sexual behavr—but the ia that a “gay gene” might lie somewhere Xq28—or elsewhere—was ptivatg.

GAY GEICSMOST OF BELIEVE THAT WE WERE BORN THAT WAY, BUT IS SEXUAL ORIENTATN OUR DNA? JV CHAMARY GO SEARCH OF THE GAY GENEJV CHAMARYPUBLISHED: MAY 31, 2009 AT 11:00 PMGAY GEICS

Zeke Stok, chief programs officer of the LGBTQ advocy anizatn GLAAD, ncurred an emailed statement: “This new study provis even more evince that beg gay or lbian is a natural part of human life, a ncln that has been drawn by rearchers and scientists time and aga. Others have warned that the search for a geic e would pathologize homosexualy the same way psychology did the twentieth century: efforts by psychoanalysts such as Irvg Bieber led to the cln of homosexualy the Amerin Psychiatric Associatn’s Diagnostic and Statistil Manual of Mental Disorrs until 1972. As noted above, the gen that rrelated wh same-sex sexual behavr also rrelated wh willgns to take risks, a nnectn that might not hold up cultur where homosexualy is ls stigmatized and those who are ls risk tolerant would therefore feel more able to act openly.

IS THERE A 'GAY GENE'? THE PROBLEM WH STUDI NNECTG GEICS AND LGBTQ INTY

The news this week that the largt study of s kd failed to nfirm the existence of a "gay gene" is not so much a disappotment for those lookg to unrstand the LGBTQ muny, as is an acknowledgement that science do not need to tell what should be plaly obv: gays, lbians, bisexuals and pansexuals are who they are.

But here's the quote that will light opponents of LGBTQ rights, some of whom sist they n "nvert" gay people to choose to be straight by prayg the gay away:. "There is no ‘gay gene’ that term whether someone has same-sex partners, ” said Ganna, who is also a geicist at the Broad Instute of MIT and Harvard as well as the Universy of Helski. While the variatns the gen are not enough to raise a rabow flag and label anyone as unqutnably gay, the rearchers say the blogil variants may at the very least partly fluence sexual behavr.

THE 'GAY GENE' IS A TOTAL MYTH, MASSIVE STUDY CONCLUS

This new rearch, he said “provis even more evince that beg gay or lbian is a natural part of human life, a ncln that has been drawn by rearchers and scientists time and aga. Geics nnot tell "the whole story, " as Eric Vila, director of the Center for Geic Medice Rearch at Children’s Natnal Health System, told the Post, about what "mak" somebody gay. Intertgly, Wtern society, homosexual men, pared wh heterosexual men, tend to rell higher levels of separatn anxiety—the distrs rultg om beg separated om major attachment figur, such as one’s primary regiver or close fay members.

Mux showed elevated rat of childhood separatn anxiety when pared wh heterosexual men, siar to what has been seen gay men Canada and fa’afafe Samoa. This is clear when we thk about how prev beliefs around homosexualy beg learned were once ed to jtify now discreded attempts to change the sir. The etlogy of homosexualy, blogil or otherwise, should have no bearg on gay dividuals’ right to you a scientist who specializ nroscience, gnive science, or psychology?

They asked more than 477, 000 participants whether they had ever had sex wh someone of the same sex, and also qutns about sexual fantasi and the gree to which they intified as gay or straight. “A lot of people want to unrstand the blogy of homosexualy, and science has lagged behd that human tert, ” says William Rice, an evolutnary geicist at the Universy of California, Santa Barbara, who also was not volved the work.

'GAY GEN': SCIENCE IS ON THE RIGHT TRACK, WE'RE BORN THIS WAY. LET’S AL WH .

We have known for s that sexual orientatn is partly herable men, thanks to studi of fai which some people are straight and some people are gay. In 1993, geic variatns a regn on the X chromosome men were lked to whether they were heterosexual or homosexual, and 1995, a regn on chromosome 8 was intified.

NO ‘GAY GENE’: MASSIVE STUDY HOM ON GEIC BASIS OF HUMAN SEXUALY

Grave’s disease is more mon gay than straight men, and some rearch suggts that gay men tend to be thner – which might possibly be a rult of thyroid overdrive.

MANY GEN INFLUENCE SAME-SEX SEXUALY, NOT A SGLE ‘GAY GENE’

The latt fdgs open the prospect to intifyg the whole pathway of gen volved both homosexual and heterosexual orientatn, says Dean Hamer at the US Natnal Instut of Health, who led the study that ppoted chromosome X back 1993.

“Conservative, right-wg people hated bee they felt that was sayg that beg gay is like beg black, that was -born, that would somehow ‘exce’ gay people or give them more rights, ” says Hamer. “On the other hand, gay people hated too bee, at that time, there were fears that the disvery would be mised to abort gay babi and wipe gay people off the face of the Earth.

Although the fears rema, recent years the search for ‘gay gen’ has bee more accepted by the gay muny, no small part bee a blogil explanatn wouldunrme arguments that beg gay is a social or liftyle choice. For stance, intil tw brothers (siblgs rived om the same fertilised egg) are more likely to both be gay than aternal tws (tws that velop om separate eggs). Now chief of the gene stcture and regulatn sectn at the US Natnal Cancer Instute, his study revealed a cur pattern: gay men tend to have more gay uncl and gay male s on their mother’s si of the fay than on their father’s.

IS THERE A “GAY GENE"?

To track down the DNA regn lked to the gay tra, Hamer ed a technique lled ‘lkage mappg’, an approach that lets geicists fd a gene even when they don’t know what do or where ’s loted. Lkage mappg works bee close relativ like brothers share not only a particular tra, such as homosexualy, but also the gen unrlyg the tra. So, if you study many pairs of gay brothers and fd a DNA regn that’s the same more than 50 per cent of s, ’s likely to be lked to homosexualy.

Asi om a few superficial differenc (among them penis and rg-fger length – both longer homosexuals), gay and straight men’s bodi appear the same. The exceptn is homosexual men’s bras, which show remarkable siari to the bras of heterosexual women, suggtg that sexual orientatn pends on the effect hormon have on the velopg bra.

IS THERE A "GAY GENE"? MAJOR NEW STUDY SAYS NO

In 1996 Blanchard and Profsor Tony Bogaert revealed a peculiar phenomenon: the more olr brothers a boy has, the greater their chanc of beg homosexual. Blanchard believ that homosexualy is “100 per cent blogil”, and timat that the aternal birth orr effect acunts for 15-30 per cent of gay men the populatn. Not only did he replite Blanchard’s birth orr effect, he also tected herance of homosexualy on the mother’s si, supportg Hamer’s ia of a gay gene on chromosome X.