The life of the gay gene: om hypothetil geic marker to social realy - PubMed

Contents:

• THERE IS NO ‘GAY GENE.’ THERE IS NO ‘STRAIGHT GENE.’ SEXUALY IS JT PLEX, STUDY NFIRMS
• NO ‘GAY GENE’: MASSIVE STUDY HOM ON GEIC BASIS OF HUMAN SEXUALY
• WHAT DO THE NEW ‘GAY GEN’ TELL ABOUT SEXUAL ORIENTATN?
• THE LIFE OF THE GAY GENE: OM HYPOTHETIL GEIC MARKER TO SOCIAL REALY
• SEARCH FOR 'GAY GEN' COM UP SHORT IN LARGE NEW STUDY

THERE IS NO ‘GAY GENE.’ THERE IS NO ‘STRAIGHT GENE.’ SEXUALY IS JT PLEX, STUDY NFIRMS

The study of nearly a half ln people clos the door on the bate around the existence of a so-lled “gay gene.

It is worth keepg md that this study only vers some typ of sexualy — gay, lbian and cis-straight — but don’t offer many sights to genr inty.

NO ‘GAY GENE’: MASSIVE STUDY HOM ON GEIC BASIS OF HUMAN SEXUALY

Humans have tried to unrstand human sexualy for centuri — and geics rearchers joed the ay the early 1990s after a seri of studi on tws suggted homosexualy ran fai. “As a teenager tryg to unrstand myself and unrstand my sexualy, I looked at the ter for “the gay gene” and obvly me across Xq28, ” said Fah Sathirapongsasuti, a study -thor and senr scientist at 23andMe, which he joked once led him to believe he hered his gayns om his mother.

“We worried a lot about volunteer bias, ” said Bailey, whose rearch clus a wily publicized study on Xq28 and gay brothers om 2018. Sanrs llaborated wh Bailey on those earlier studi and said their work had always admted that there was no sgle “gay gene. The rearchers had members of the same-sex muny review the study’s sign and language, and they adm that their termology and fns for gay, lbian and heterosexual do not reflect the full nature of the sexualy ntuum.

WHAT DO THE NEW ‘GAY GEN’ TELL ABOUT SEXUAL ORIENTATN?

“[Our study] unrsr an important role for the environment shapg human sexual behavr and perhaps most importantly there is no sgle gay gene but rather the ntributn of many small geic effects sttered across the genome, ” Neale said.

“There is no ‘gay gene’, ” says lead study thor Andrea Ganna, a geicist at the Broad Instute of MIT and Harvard Cambridge, and his lleagu also ed the analysis to timate that up to 25% of sexual behavur n be explaed by geics, wh the rt fluenced by environmental and cultural factors — a figure siar to the fdgs of smaller studi. Those who nsir beg gay a disadvantage life (which still is, certa societi), might regard gay people differently if they knew that beg gay was an hered tra, rather than a nsequence of life events, such as a particular type of upbrgg, or mixg wh certa sorts of iends or even a liberate cisn.

The law also might take a different view those untri (aga, there are still many) which beg gay is a crimal offense. An early study claimed that if one pair of (male) intil tws (who have intil geic patterns) was gay, there was a 100 percent chance of the other one also beg gay.

THE LIFE OF THE GAY GENE: OM HYPOTHETIL GEIC MARKER TO SOCIAL REALY

It was quickly shown that, fact, the real chance of two intil tws beg gay was around 40-50 percent, whereas was ls non-intil on, though still somewhat greater than the general populatn. There was another, much smaller, group who said they were entirely gay (about 6 percent), and a stterg of even smaller numbers who claimed to be bisexual. Firstly, they found very few gen whose variatns were rrelated wh beg gay, or even havg a sgle same-sex partner.

We have known for s that sexual orientatn is partly herable men, thanks to studi of fai which some people are straight and some people are gay.

SEARCH FOR 'GAY GEN' COM UP SHORT IN LARGE NEW STUDY

In 1993, geic variatns a regn on the X chromosome men were lked to whether they were heterosexual or homosexual, and 1995, a regn on chromosome 8 was intified. Alan Sanrs at North Shore Universy, Illois, and his team ppoted the gen by parg DNA om 1077 gay and 1231 straight men.

Intertgly, this bra regn ntas the hypothalam, which was intified 1991 as differg size between gay and straight men. Grave’s disease is more mon gay than straight men, and some rearch suggts that gay men tend to be thner – which might possibly be a rult of thyroid overdrive.

There have been studi suggtg that there is a geic element to homosexualy women, but more rearch has been done men, says Sanrs. The latt fdgs open the prospect to intifyg the whole pathway of gen volved both homosexual and heterosexual orientatn, says Dean Hamer at the US Natnal Instut of Health, who led the study that ppoted chromosome X back 1993. The gay gene was first intified 1993 as a rrelatn between the geic marker Xq28 and gay male sexualy.